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1

Imidazo[4,5-c]quinolines as inhibitors of the PI3K/PKB-pathway

Frédéric Stauffer, Sauveur-Michel Maira, Pascal Furet, Carlos García-Echeverría

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 365 KB

english, 2008

2

PI3K and mTOR inhibitors — a new generation of targeted anticancer agents

Saskia Brachmann, Christine Fritsch, Saveur-Michel Maira, Carlos García-Echeverría

Journal:

Current Opinion in Cell Biology

Year:

2009

Language:

english

File:

PDF, 169 KB

english, 2009

3

Blocking the PI3K/PKB Pathway in Tumor Cells

Stauffer, F., Holzer, P., Garcia-Echeverria, C.

Journal:

Current Medicinal Chemistry - Anti-Cancer Agents

Year:

2005

Language:

english

File:

PDF, 160 KB

english, 2005

4

ATP site-directed competitive and irreversible inhibitors of protein kinases

Carlos García-Echeverría, Peter Traxler, Dean B. Evans

Journal:

Medicinal Research Reviews

Year:

2000

Language:

english

File:

PDF, 284 KB

english, 2000

5

Conformational analysis of two cyclic disulfide peptides

C. García-Echeverría, G. Siligardi, P. Mascagni, W. Gibbons, E. Giralt, M. Pons

Journal:

Year:

1991

Language:

english

File:

PDF, 636 KB

english, 1991

6

ChemInform Abstract: Polyamide Based Nucleic Acid Analogues - Synthesis of δ-Amino Acids with Nucleic Acid Bases Bearing Side Chains.

K.-H. ALTMANN, C. SCHMIT CHIESI, C. GARCIA-ECHEVERRIA

Journal:

Year:

1997

File:

PDF, 35 KB

1997

7

ChemInform Abstract: Structure-Based Design of Peptidomimetic Ligands of the Grb2-SH2 Domain.

J. SCHOEPFER, B. GAY, G. CARAVATTI, C. GARCIA-ECHEVERRIA, H. FRETZ, J. RAHUEL, P. FURET

Journal:

Year:

1999

File:

PDF, 32 KB

1999

8

ChemInform Abstract: Highly Potent Inhibitors of the Grb2-SH2 Domain.

Joseph Schoepfer, Heinz Fretz, Brigitte Gay, Pascal Furet, Carlos Garcia-Echeverria, Nicole End, Giorgio Caravatti

Journal:

Year:

1999

File:

PDF, 30 KB

1999

9

ChemInform Abstract: ATP Site-Directed Competitive and Irreversible Inhibitors of Protein Kinases

Carlos Garcia-Echeverria, Peter Traxler, Dean B. Evans

Journal:

Year:

2000

File:

PDF, 24 KB

2000

10

ChemInform Abstract: Synthesis and Hybridization Properties of Polyamide Based Nucleic Acid Analogues Incorporating Pyrrolidine-Derived Nucleoamino Acids.

Karl-Heinz Altmann, Dieter Huesken, Bernard Cuenoud, Carlos Garcia-Echeverria

Journal:

Year:

2000

File:

PDF, 32 KB

2000

11

Preparation of Glyco-, Phospho-, and Sulfopeptides

Carlos Garcia-Echeverria

Journal:

Year:

2001

File:

PDF, 23 KB

2001

12

ChemInform Abstract: A New Structural Class of Selective and Non-Covalent Inhibitors of the Chymotrypsin-Like Activity of the 20S Proteasome.

C. Garcia-Echeverria, P. Imbach, D. France, P. Fuerst, M. Lang, M. Noorani, D. Scholz, J. Zimmermann, P. Furet

Journal:

Year:

2001

File:

PDF, 27 KB

2001

13

Synthesis, surface, and cell-adhesion properties of polyurethanes containing covalently grafted RGD-peptides

Horng-Ban Lin, Wen Sun, Deane F. Mosher, Carlos García-Echeverría, Kenneth Schaufelberger, Peter I. Lelkes, Stuart L. Cooper

Journal:

Journal of Biomedical Materials Research Part B: Applied Biomaterials

Year:

1994

Language:

english

File:

PDF, 1.36 MB

english, 1994

14

Comparative studies of the coupling of N-methylated, sterically hindered amino acids during solid-phase peptide synthesis

Yvonne M. Angell, Carlos García-Echeverría, Daniel H. Rich

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 380 KB

english, 1994

15

Endothelial cell adhesion on polyurethanes containing covalently attached RGD-peptides

Horng-Ban Lin, Carlos García-Echeverría, Shinji Asakura, Wen Sun, Deane F. Mosher, Stuart L. Cooper

Journal:

Year:

1992

Language:

english

File:

PDF, 2.71 MB

english, 1992

16

Disruption of coiled coil formation by methionine oxidation

Carlos García-Echeverría

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 262 KB

english, 1996

17

Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment

Carlos García-Echeverría

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 320 KB

english, 2010

18

A convenient method for the preparation of oligonucleotide 5′-phosphates

Carlos García-Echeverría, Robert Häner

Journal:

Year:

1996

Language:

english

File:

PDF, 356 KB

english, 1996

19

S-2-(2,4-dinitrophenyl)ethyl-L-cysteine: a new derivative for solid-phase peptide synthesis

Miriam Royo, Carlos García-Echeverría, Ernest Giralt, Ramon Eritja, Fernando Albericio

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 320 KB

english, 1992

20

Convenient synthesis of a cyclic peptide disulfide: A type II β-turn structural model

Carlos García-Echeverría, Fernando Albericio, Miquel Pons

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 274 KB

english, 1989

21

A base labile handle for solid phase organic chemistry

Carlos García-Echeverría

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 104 KB

english, 1997

22

Synthesis and fluorescence properties of a substrate for a continuous fluorimetric assay of protein tyrosine phosphatases

Carlos García-Echeverría, Daniel H. Rich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 324 KB

english, 1993

23

Synthesis and ion-binding properties of an immobilized bis-cysteine peptide

Carlos García-Echeverría, Miquel Pons, Ernest Giralt, Fernando Albericio

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1992

Language:

english

File:

PDF, 333 KB

english, 1992

24

Novel polyamide based nucleic acid analogs-synthesis of oligomers and RNA-binding properties

Carlos García-Echeverría, Dieter Hüsken, Chantal Schmit Chiesi, Karl-Heinz Altmann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 285 KB

english, 1997

25

Polyamide based nucleic acid analogs — synthesis of δ-amino acids with nucleic acid bases bearing side chains

Karl-Heinz Altmann, Chantal Schmit Chiesi, Carlos García-Echeverría

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 280 KB

english, 1997

26

Probing the formation of a parallel heterodimeric coiled coil by fluorescence quenching

Carlos García-Echeverría

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 247 KB

english, 1997

27

Structure-based design of peptidomimetic ligands of the Grb2-SH2 domain

Joseph Schoepfer, Brigitte Gay, Giorgio Caravatti, Carlos Garcia-Echeverria, Heinz Fretz, Joseph Rahuel, Pascal Furet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 292 KB

english, 1998

28

Highly potent inhibitors of the Grb2-SH2 domain

Joseph Schoepfer, Heinz Fretz, Brigitte Gay, Pascal Furet, Carlos García-Echeverría, Nicole End, Giorgio Caravatti

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 275 KB

english, 1999

29

Mapping the X+1 binding site of the Grb2-SH2 domain with α,α-disubstituted cyclic α-amino acids

Carlos García-Echeverría, Brigitte Gay, Joseph Rahuel, Pascal Furet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 1.18 MB

english, 1999

30

Evaluation of coupling conditions for the incorporation ofNα-Fmoc-Tyr(PO3H2)-OH in solid-phase peptide synthesis

Carlos García-Echeverría

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1996

Language:

english

File:

PDF, 305 KB

english, 1996

31

The leucine zipper domain of the Max gene product is not an autonomous dimerization site

Carlos García-Echeverría

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1995

Language:

english

File:

PDF, 529 KB

english, 1995

32

Kinetic studies of papain: Effect of P3′ substituents and donor/acceptor pairs of intramolecularly quenched fluorogenic substrates

Carlos García-Echeverría, Daniel H. Rich

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1995

Language:

english

File:

PDF, 417 KB

english, 1995

33

Potential pyrophosphate formation upon use ofNα-Fmoc-Tyr(PO3H2)-OH in solid-phase peptide synthesis

Carlos García-Echeverría

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1995

Language:

english

File:

PDF, 361 KB

english, 1995

34

Biotinylated phosphotyrosine containing peptides: A valuable tool for studies on phosphopeptide interactions with SH2 and PTB domains

Carlos García-Echeverría, Christelle Stamm, Roman Wille, Dorothee Arz, Brigitte Gay

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1997

Language:

english

File:

PDF, 452 KB

english, 1997

35

Methionine-containing zipper peptides

Carlos García-Echeverría

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1997

Language:

english

File:

PDF, 383 KB

english, 1997

36

Design of a Coiled-Coil-based Model Peptide System to Explore the Fundamentals of Amyloid Fibril Formation

Michel O. Steinmetz, Carlos García-Echeverría, Richard A. Kammerer

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2005

Language:

english

File:

PDF, 504 KB

english, 2005

37

Peptide and Peptide-Like Modulators of 20S Proteasome Enzymatic Activity in Cancer Cells

Carlos García-Echeverría

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2006

Language:

english

File:

PDF, 315 KB

english, 2006

38

Editorial

Carlos García-Echeverría

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2006

Language:

english

File:

PDF, 119 KB

english, 2006

39

Protein and lipid kinase inhibitors as targeted anticancer agents of the Ras/Raf/MEK and PI3K/PKB pathways

Carlos García-Echeverría

Journal:

Purinergic Signalling

Year:

2009

Language:

english

File:

PDF, 197 KB

english, 2009

40

Novel β-lactam derivatives: Potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome

Patricia Imbach, Marc Lang, Carlos García-Echeverría, Vito Guagnano, Maria Noorani, Johannes Roesel, Francis Bitsch, Grety Rihs, Pascal Furet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 334 KB

english, 2007

41

The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells

Patricia Maiso, Enrique M. Ocio, Mercedes Garayoa, Juan C. Montero, Francesco Hofmann, Carlos García-Echeverría, Johann Zimmermann, Atanasio Pandiella, Jesús F. San Miguel

Journal:

British Journal of Haematology

Year:

2008

Language:

english

File:

PDF, 403 KB

english, 2008

42

Anti-myeloma activity of the novel 2-aminothienopyrimidine Hsp90 inhibitor NVP-BEP800

Thorsten Stühmer, Manik Chatterjee, Evelyn Grella, Ruth Seggewiss, Christian Langer, Sabine Müller, Joseph Schoepfer, Carlos Garcia-Echeverria, Cornelia Quadt, Michael R. Jensen, Hermann Einsele, Ralf

Journal:

British Journal of Haematology

Year:

2009

Language:

english

File:

PDF, 429 KB

english, 2009

43

Identification of key residues involved in mediating the in vivo anti-tumor/anti-endothelial activity of Alphastatin

C. A. STATON, S. M. STRIBBLING, C. GARCÍA-ECHEVERRÍA, J. P. BURY, S. TAZZYMAN, C. E. LEWIS, N. J. BROWN

Journal:

Journal of Thrombosis and Haemostasis

Year:

2007

Language:

english

File:

PDF, 772 KB

english, 2007

44

Structural basis for specificity of GRB2-SH2 revealed by a novel ligand binding mode

Rahuel, Joseph, Gay, Brigitte, Erdmann, Dirk, Strauss, André, García-Echeverría, Carlos, Furet, Pascal, Caravatti, Giorgio, Fretz, Heinz, Schoepfer, Joseph, Grütter, Markus G.

Journal:

Natural Structural Biology

Year:

1996

File:

PDF, 551 KB

1996

45

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

Garcia-Echeverria, C, Sellers, W R

Journal:

Year:

2008

Language:

english

File:

PDF, 343 KB

english, 2008

46

Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts

Cao, P, Maira, S-M, García-Echeverría, C, Hedley, D W

Journal:

British Journal of Cancer

Year:

2009

Language:

english

File:

PDF, 487 KB

english, 2009

47

Comparative study of the p53-mdm2 and p53-MDMX interfaces

Böttger, Volker, Böttger, Angelika, Garcia-Echeverria, Carlos, Ramos, Yolande FM, van der Eb, Alex J, Jochemsen, Aart G, Lane, David P

Journal:

Year:

1999

Language:

english

File:

PDF, 450 KB

english, 1999

48

Inhibition of Aurora A in response to DNA damage

Krystyniak, A, Garcia-Echeverria, C, Prigent, C, Ferrari, S

Journal:

Year:

2005

Language:

english

File:

PDF, 477 KB

english, 2005

49

Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines

Urbanska, K, Trojanek, J, Del Valle, L, Eldeen, M B, Hofmann, F, Garcia-Echeverria, C, Khalili, K, Reiss, K

Journal:

Year:

2006

Language:

english

File:

PDF, 246 KB

english, 2006

50

Biotinylated phosphotyrosine containing peptides: A valuable tool for studies on phosphopeptide interactions with SH2 and PTB domains

Carlos García-Echeverría, Christelle Stamm, Roman Wille, Dorothee Arz, Brigitte Gay

Journal:

International Journal of Peptide Research and Therapeutics

Year:

1997

Language:

english

File:

PDF, 59 KB

english, 1997

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